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efficacy against s pneumoniae atcc 10813  (ATCC)


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    ATCC efficacy against s pneumoniae atcc 10813
    Efficacy Against S Pneumoniae Atcc 10813, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 54 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/efficacy+against+s+pneumoniae+atcc+10813/Streptococcus+pneumoniae+(Klein)+Chester/pmc02565885-130-49-53
    Average 94 stars, based on 54 article reviews
    efficacy against s pneumoniae atcc 10813 - by Bioz Stars, 2026-10
    94/100 stars

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    Infection:

    Article Title: Pharmacodynamics of the New Des-F(6)-Quinolone Garenoxacin in a Murine Thigh Infection Model
    Article Snippet: .. These analyses suggest that treatment efficacy was dependent upon dose level and independent of the dosing intervals studied. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 3. caption a7 (a) The relationship between the garenoxacin dosing interval and efficacy against S. pneumoniae ATCC 10813 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. (b) The relationship between the garenoxacin dosing interval and efficacy against S. aureus ATCC 33591 in a murine thigh infection model. Each symbol represents the mean data per mouse from two thighs. table ft1 table-wrap mode="anchored" t5 TABLE 2. caption a7 Dosing interval ED 25 (95% CI) a ED 50 (95% CI) ED 75 (95% CI) Static dose (95% CI) 1 log kill (95% CI) S. pneumoniae q3h 11.5 (8.2-14.8) 23 (16.3-29.7) 46.2 (32.8-59.6) 18.2 (12.9-23.5) 25.8 (18.3-33.3) q6h 8.3 (3.7-12.8) 18.4 (8.2-28.6) 41.1 (18.5-63.7) 16 (7.2-24.8) 25 (11.2-38.8) q12h 14.4 (0.6-28.2) 31 (0.7-61.3) 64 (3-125) 31 (0.7-61.3) 50.3 (23.3-78.3) q24h 12.9 (1.0-24.9) 38.8 (1.2-76.4) 115 (111-227) 65.7 (1.7-130) >128 S. aureus q3h 2.85 (2.6-3.1) 3.40 (3.1-3.8) 4.96 (4.5-5.5) 4.33 (3.9-4.8) 5.84 (5.3-6.4) q6h 1.05 (1.0-1.2) 4.07 (2.9-5.2) 15.9 (11.1-20.5) 10.0 (7.0-13.0) 30 (21.1-38.1) q12h 1.56 (1.4-1.8) 3.44 (3.0-3.8) 7.60 (6.7-8.5) 5.95 (5.0-7.0) 11.5 (10.1-12.9) q24h 2.9 (1.5-4.3) 7.46 (3.8-11.1) 19.1 (9.7-28.5) 7.91 (4.0-11.8) 26.6 (13.6-39.6) Open in a separate window a CI, confidence interval. .. Impact of garenoxacin dosing interval on in vivo efficacy against S. pneumoniae 10813 and S. aureus 33591 The relationships between microbiologic effect and each of the pharmacodynamic parameters, 24-h AUC/MIC, percent T >MIC, and peak/MIC, against S. pneumoniae ATCC 10813 are shown in Fig. . As with fluoroquinolone antibiotics, the strongest relationship was seen when results were correlated with the 24-h AUC/MIC ratio, with an R 2 value of 90% ( 2 , 3 , 5 , 6 , 9 , 10 ).

    Article Title: In Vivo Pharmacodynamics of Ceftobiprole against Multiple Bacterial Pathogens in Murine Thigh and Lung Infection Models
    Article Snippet: .. Figure illustrates the relationship between T > MIC and the activity of ceftobiprole against these two organisms at both sites of infection. fig ft0 fig mode=article f1 FIG. 4. caption a4 Relationship of T > MIC for 6-h dosing of increasing doses of ceftobiprole with its efficacy against S. pneumoniae ATCC 10813 and K. pneumoniae ATCC 43816 in the thighs and lungs of neutropenic mice. ..

    Article Title: Pharmacodynamics of a New Cephalosporin, PPI-0903 (TAK-599), Active against Methicillin-Resistant Staphylococcus aureus in Murine Thigh and Lung Infection Models: Identification of an In Vivo Pharmacokinetic-Pharmacodynamic Target
    Article Snippet: .. These dose regimen relationships indicate that treatment efficacy was dependent upon the dosing intervals studied and suggest that efficacy was driven by the %T>MIC index. fig ft0 fig mode=article f1 FIG.3. caption a4 Relationship between PPI-0903 dosing interval and efficacy against S. pneumoniae ATCC 10813 (a), S. aureus ATCC 33591 (b), and K. pneumoniae ATCC 43816 (c) in a murine thigh infection model. Each symbol represents the mean data from two mice (four thighs). ..

    Activity Assay:

    Article Title: In Vivo Pharmacodynamics of Ceftobiprole against Multiple Bacterial Pathogens in Murine Thigh and Lung Infection Models
    Article Snippet: .. Figure illustrates the relationship between T > MIC and the activity of ceftobiprole against these two organisms at both sites of infection. fig ft0 fig mode=article f1 FIG. 4. caption a4 Relationship of T > MIC for 6-h dosing of increasing doses of ceftobiprole with its efficacy against S. pneumoniae ATCC 10813 and K. pneumoniae ATCC 43816 in the thighs and lungs of neutropenic mice. ..

    Article Title: In Vivo Pharmacodynamics of Ceftobiprole against Multiple Bacterial Pathogens in Murine Thigh and Lung Infection Models
    Article Snippet: .. Figure illustrates the relationship between T > MIC and the activity of ceftobiprole against these two organisms in thighs of mice with and without neutropenia. fig ft0 fig mode=article f1 FIG. 5. caption a4 Relationship of T > MIC for 6-h dosing of increasing doses of ceftobiprole with its efficacy against S. pneumoniae ATCC 10813 and K. pneumoniae ATCC 43816 in the thighs of normal (nonneutropenic) and neutropenic mice. ..

    Protein-Protein interactions:

    Article Title: Pharmacodynamics of a New Cephalosporin, PPI-0903 (TAK-599), Active against Methicillin-Resistant Staphylococcus aureus in Murine Thigh and Lung Infection Models: Identification of an In Vivo Pharmacokinetic-Pharmacodynamic Target
    Article Snippet: .. These dose regimen relationships indicate that treatment efficacy was dependent upon the dosing intervals studied and suggest that efficacy was driven by the %T>MIC index. fig ft0 fig mode=article f1 FIG.3. caption a4 Relationship between PPI-0903 dosing interval and efficacy against S. pneumoniae ATCC 10813 (a), S. aureus ATCC 33591 (b), and K. pneumoniae ATCC 43816 (c) in a murine thigh infection model. Each symbol represents the mean data from two mice (four thighs). ..



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